Autoantibodies in Rheumatology

Autoantibody	Condition	Comments
ANA	SLE	Screening tool for Autoimmunity
Anti DS DNA	SLE	Correlates with Lupus disease activity esp kidney disease
Anti Smith	SLE	Most speicifc for SLE
Anti U1 RNP	MCTD, SLE	Higher titre seen in MCTD
Anti Ro/SSA, Anti LA/SSB	Sjogrens, RA, SLE, PSS	SICCA symptoms in SLE, associated with neonatal lupus
Anti SCL 70	Diffuse PSS	Pulmonary fibrosis more common
Anti centromere	Limited PSS (CREST)	Pulmonary HTN
c-ANCA (antiproteinase-3)	GPA
p-ANCA (antimyeloperoxidase)	MPA/ Churg strauss	Atypical p-ANCA seen in IBD
Anti Jo1	Myositis	ILD
RF	RA, Sjogrens, Cryoglobulinaemia	Antibody to Ig hence many false positives
Anti CCP	RA	Positive in 1/3rd RF negative patients
Anti histones	Drug induced SLE	Also seen in Native Lupus
Cryoglobulins	Vasculitis, hep C, myeloma, SLE, RA	Type 2 seen in cryoglobulinemic vasculitis